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leptomycin b  (MedChemExpress)
94
MedChemExpress leptomycin b
(A) Immunofluorescence staining of HDAC1 (red) and viral ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± <t>leptomycin</t> <t>B</t> (LMB; 10 nM; 24 h). Scale bar: 10 μm. (B) CHX chase assay measuring HDAC1/2 degradation kinetics in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (C) Ubiquitination assay of HDAC1 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). (D) Immunofluorescence analysis of MDM2 (red) and ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). Scale bar: 10 μm. (E) Immunoblotting analysis of DDR markers (γ-H2AX) and HDAC1/2 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (F) Viral titers in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). Data are mean ± SEM; n = 3. * P < 0.05, ** P < 0.01, *** P < 0.001
Leptomycin B, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
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lmb  (TargetMol)
94
TargetMol lmb
(A) Immunofluorescence staining of HDAC1 (red) and viral ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± <t>leptomycin</t> <t>B</t> (LMB; 10 nM; 24 h). Scale bar: 10 μm. (B) CHX chase assay measuring HDAC1/2 degradation kinetics in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (C) Ubiquitination assay of HDAC1 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). (D) Immunofluorescence analysis of MDM2 (red) and ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). Scale bar: 10 μm. (E) Immunoblotting analysis of DDR markers (γ-H2AX) and HDAC1/2 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (F) Viral titers in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). Data are mean ± SEM; n = 3. * P < 0.05, ** P < 0.01, *** P < 0.001
Lmb, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/lmb/product/TargetMol
Average 94 stars, based on 1 article reviews
lmb - by Bioz Stars, 2026-03
94/100 stars
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leptomycin b  (Cell Signaling Technology Inc)
95
Cell Signaling Technology Inc leptomycin b
(A) Immunofluorescence staining of HDAC1 (red) and viral ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± <t>leptomycin</t> <t>B</t> (LMB; 10 nM; 24 h). Scale bar: 10 μm. (B) CHX chase assay measuring HDAC1/2 degradation kinetics in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (C) Ubiquitination assay of HDAC1 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). (D) Immunofluorescence analysis of MDM2 (red) and ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). Scale bar: 10 μm. (E) Immunoblotting analysis of DDR markers (γ-H2AX) and HDAC1/2 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (F) Viral titers in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). Data are mean ± SEM; n = 3. * P < 0.05, ** P < 0.01, *** P < 0.001
Leptomycin B, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/leptomycin b/product/Cell Signaling Technology Inc
Average 95 stars, based on 1 article reviews
leptomycin b - by Bioz Stars, 2026-03
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leptomycin b  (Beyotime)
90
Beyotime leptomycin b
(A) Immunofluorescence staining of HDAC1 (red) and viral ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± <t>leptomycin</t> <t>B</t> (LMB; 10 nM; 24 h). Scale bar: 10 μm. (B) CHX chase assay measuring HDAC1/2 degradation kinetics in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (C) Ubiquitination assay of HDAC1 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). (D) Immunofluorescence analysis of MDM2 (red) and ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). Scale bar: 10 μm. (E) Immunoblotting analysis of DDR markers (γ-H2AX) and HDAC1/2 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (F) Viral titers in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). Data are mean ± SEM; n = 3. * P < 0.05, ** P < 0.01, *** P < 0.001
Leptomycin B, supplied by Beyotime, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/leptomycin b/product/Beyotime
Average 90 stars, based on 1 article reviews
leptomycin b - by Bioz Stars, 2026-03
90/100 stars
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nuclear export inhibitor leptomycin b s1726  (Beyotime)
90
Beyotime nuclear export inhibitor leptomycin b s1726
(A) Immunofluorescence staining of HDAC1 (red) and viral ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± <t>leptomycin</t> <t>B</t> (LMB; 10 nM; 24 h). Scale bar: 10 μm. (B) CHX chase assay measuring HDAC1/2 degradation kinetics in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (C) Ubiquitination assay of HDAC1 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). (D) Immunofluorescence analysis of MDM2 (red) and ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). Scale bar: 10 μm. (E) Immunoblotting analysis of DDR markers (γ-H2AX) and HDAC1/2 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (F) Viral titers in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). Data are mean ± SEM; n = 3. * P < 0.05, ** P < 0.01, *** P < 0.001
Nuclear Export Inhibitor Leptomycin B S1726, supplied by Beyotime, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/nuclear export inhibitor leptomycin b s1726/product/Beyotime
Average 90 stars, based on 1 article reviews
nuclear export inhibitor leptomycin b s1726 - by Bioz Stars, 2026-03
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(A) Immunofluorescence staining of HDAC1 (red) and viral ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± leptomycin B (LMB; 10 nM; 24 h). Scale bar: 10 μm. (B) CHX chase assay measuring HDAC1/2 degradation kinetics in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (C) Ubiquitination assay of HDAC1 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). (D) Immunofluorescence analysis of MDM2 (red) and ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). Scale bar: 10 μm. (E) Immunoblotting analysis of DDR markers (γ-H2AX) and HDAC1/2 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (F) Viral titers in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). Data are mean ± SEM; n = 3. * P < 0.05, ** P < 0.01, *** P < 0.001

Journal: bioRxiv

Article Title: The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication

doi: 10.64898/2026.01.02.697337

Figure Lengend Snippet: (A) Immunofluorescence staining of HDAC1 (red) and viral ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± leptomycin B (LMB; 10 nM; 24 h). Scale bar: 10 μm. (B) CHX chase assay measuring HDAC1/2 degradation kinetics in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (C) Ubiquitination assay of HDAC1 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). (D) Immunofluorescence analysis of MDM2 (red) and ICP4 (green) in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM; 24 h). Scale bar: 10 μm. (E) Immunoblotting analysis of DDR markers (γ-H2AX) and HDAC1/2 in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). (F) Viral titers in HSV-1-infected HeLa cells (MOI = 1) ± LMB (10 μM). Data are mean ± SEM; n = 3. * P < 0.05, ** P < 0.01, *** P < 0.001

Article Snippet: Reagents were sourced as follows: Leptomycin B (HY-16909), MG-132 (HY-13259), 3-MA (HY-19312), cycloheximide (HY-12320), and chloroquine (HY-17589A) were purchased from MedChemExpress; berzosertib (S7102) was purchased from Selleck; DMSO (W387520) was purchased from Sigma-Aldrich.

Techniques: Immunofluorescence, Staining, Infection, Ubiquitin Proteomics, Western Blot